Prepare ingredients: Drain the pimentos well so the mixture stays thick and creamy.
Mix: In a medium bowl, combine shredded cheddar cheese, mayonnaise, pimentos, garlic powder, onion powder, paprika, cayenne (if using), salt, and pepper.
Stir until creamy: Mix well until fully combined. Adjust seasoning to taste — more mayo for creaminess, more cheese for thickness.
Chill: Cover and refrigerate for at least 1 hour to let the flavors blend.
Serve: Spread on biscuits, sandwiches, burgers, or serve as a dip with crackers and veggies.